Starting in OSX 10.9, Apple no longer provided a full working version of X11.app. Through OSX 10.8, Apple provided a means to install X11.app, but XQuartz has always been more up to date and hence is recommended for use. Running almost any GNU Radio graphical interface (GUI) will require downloading and installing X11/XQuartz first. Prerequisite: X11.app, recommended via XQuartz Primary support is for 64-bit Intel-based Macs running OSX 10.6 or newer. There is very little support for getting the background libraries and applications installed on OSX 10.5 or earlier, nor 32-bit Intel or any PPC, though all of these should be possible.
GNU Radio has been compiled and installed on OSX 10.4 ('Tiger') through 10.15 ('Catalina') running any compatible version of Xcode on all recent and many older Macs - whether Intel or PowerPC/PPC.
1.6 A note about GR_PYTHON_DIR CMake setting and the PYTHONPATH environment variable.1.5.2 Compiling GNU Radio using Kate Temkins build script.1.2 A note about DYLD_LIBRARY_PATH and other DYLD environment variables.1.1 Prerequisite: X11.app, recommended via XQuartz.1 Installing GNU Radio on MacOS X / macOS.